Pharmacogenomics: The Search for Individualized Therapies

his is the very first comprehensive coverage of pharmacogenomics - a new discipline that will revolutionize health care.

Outstanding experts in the field present an overview of the latest work in this young and promising approach and provide an insight into the recent findings for all relevant disease classes.

Indispensable for a wide audience of experts working in the various areas that contribute to this field such as pharmacology, genetics, molecular biology, pharmaceutics, medicinal chemistry and clinical medicine.

Contents

Preface
List of Contributors
Color Plates


Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations (U. Meyer)
The Human Genome (S. Broder, et al.)
Turning SNPs into Useful Makers of Drug Response (J. McCarthy)
Association Studies in Pharmacogenomics (L. Essioux, et al.)
Genomics Application that Facilitate the Understanding of Drug Action and Toxicity (L. Furness)
The Role of Pharmacogenetics in Drug Discovery and Therapeutics (K. Lindpaintner)
Pharmacogenomics and Drug Design (P. Dean, et al.)
The Pharmacogenomics of Human P-Glycoprotein (M. Fromm & M. Eichelbaum)
Pharmacogenomics of Drug Transporters (R. Tirona & R. Kim)
Pharmacogenomics of Asthma Treatment (L. Palmer, et al.)
Endothelial Cells are Targets for Hydroxy Urea: Relevance to the Current Therapeutic Strategy in Sickle Cell Disease (C. Lapouméroulie, et al.)
Pharmacogenomics and Complex Cardiovascular Disease - Clinical Studies in Candidate Genes (B. Winkelmann, et al.)
Pharmacogenomics of Lipid-Lowering Agents (M. Hoffmann, et al.)
Pharmacogenomics of Chemotherapeutic Agents in Cancer Treatment (F. Innocenti, et al.)
Pharmacogenomics of the Blood-Brain Barrier (J.-M. Scherrmann)
Pharmacogenomics and the Treatment of Neurological Disease (D. Goldstein, et al.)
Pharmacogenomics of Neurodegenerative Diseases: Examples and Perspectives (P. Hantraye, et al.)
Psychiatric Pharmacogenetics: Prediction of Treatment Outcomes in Schizophrenia (M. Masellis, et al.)
Pharmacogenomics of Major Depression and Antidepressant Treatment (M.-L. Wong, et al.)
Pharmacogenomics of Bipolar Disorder (H. Manji, et al.)
Pharmacogenomics of Alcoholism (T. Hurley, et al.)
Pharmacogenomics of Tobacco Addiction (E. Johnstone, et al.)
Pharmacogenomics of Opioid Systems (T. Reisine)
Ethnicity and Pharmacogenomics (H. McLeod & M. Ameyaw)
Pharmacogenomics: Ensuring Equity Regarding Drugs Based on Genetic Difference (P. Epps & M. Rothstein)
Translation of Vascular Proteomics into Individualized Therapeutics (R. Pasqualini & W. Arap)
Glossary of Key Terms in Molecular Genetics of Pharmacogenomics (B. Winkelmann, et al.)

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