advances in the methods used in cellular and molecular pathology. In
recent years, knowledge of the molecular organization of the cell has
led to the development of powerful new techniques that bring greater
accuracy and objectives to the diagnosis, prognosis and management of
many diseases and to the study of pathological states. This book
describes the latest molecular techniques available for the analysis
of diseases. In particular it includes new techniques using
fluorescent dyes, DNA microarrays, protein chemistry, and mass
spectrometry. It also incorporates information from the Human Genome
Project, and the new disciplines of genomics and proteomics, where
relevant to pathology. Color plates are a new feature of this edition,
illustrating the advances in fluorescence labeling of cells.
Table of Contents
Preface.
Preface to Molecular Biology in Histopathology.
List of Contributors.
Chapter 1. Blotting Techniques: Methodology and Applications (Fiona
Watson and C. Simon Herrington).
Chapter 2. In-situ Hybridisation in Histopathology (Gerald Niedobitek
and Hermann Herbst).
Chapter 3. DNA Flow Cytometry (M. G. Ormerod).
Chapter 4. Interphase Cytogenetics (Sara A. Dyer and Jonathan J. Waters).
Chapter 5. Oncogenes (Fiona Macdonald).
Chapter 6. Molecular and Immunological Aspects of Cell Proliferation
(Karl Baumforth and John Crocker).
Chapter 7. Interphase Nucleolar Organiser Regions in Tumour Pathology
(Massimo Derenzini, et al.).
Chapter 8. Apoptosis and Cell Senescence (Lee B. Jordan and David J.
Harrison).
Chapter 9. The Polymerase Chain Reaction (Timothy Diss).
Chapter 10. Laser Capture Microdissection: Techniques and Applications
in the Molecular Analysis of the Cancer Cell (Amanda Dutton, et al.).
Chapter 11. The In-situ Polymerase Chain Reaction (John J. O’Leary, et
al.).
Chapter 12. TaqMan® Technology and Real-Time Polymerase Chain Reaction
(John J. O’Leary, et al.).
Chapter 13. Gene Expression Analysis Using Microarrays (Sophie E.
Wildsmith and Fiona J. Spence).
Chapter 14. Comparative Genomic Hybridisation in Pathology (Marjan M.
Weiss, et al.).
Chapter 15. DNA Sequencing and the Human Genome Project (Philip Bennett).
Chapter 16. Monoclonal Antibodies: The Generation and Application of
’Tools of the Trade’ Within Biomedical Science (Paul N. Nelson, et al.).
Chapter 17. Proteomics (Kathryn Lilley, et al.).
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